Effect of chronic kidney disease on serum resistin level

Abstract

BACKGROUND: Chronic Kidney Diseases (CKD) of all etiologies are usually associated with Insulin Resistance (IR). Resistin is also a protein associated with IR. Some studies conducted abroad have shown that resistin level is higher among CKD patients. OBJECTIVE: To test if serum resistin level is significantly higher in CKD patients compared to normal individuals. PATIENTS AND METHODS: 96 CKD patients and 97 normal individuals were included in the study. Written informed consent was obtained from every individual. RESULTS: Serum resistin level was higher in CKD patients compared to control subjects. The difference in serum resistin level between two groups was statistically significant. CONCLUSION: Our study is probably the first study in India comparing serum resistin levels of CKD patients vis-à-vis control subjects. Further cellular research may be needed to explore this relation.