Occurrence and Properties of the Hyperpolarization-Activated Current I _f in Ventricular Myocytes From Normotensive and Hypertensive Rats During Aging

Abstract

In LVMs from both WKY and SHR, the occurrence of I(f) increases with aging. Density appears linearly related to the severity of cardiac hypertrophy and increases with beta-adrenoceptor stimulation, which suggests that I(f) may contribute to an increased propensity of the hypertrophied heart for arrhythmias.