A Practocal Prepraration of D1-2-Substituted and D1-2,3-Disubstituted Pyrrolines

Abstract

Addition of N-vinylpyrrolidinone and an ester to NaH in THF effects acylation and affords keto lactams (1) in high yields. Hydrolysis of 1 in strong acid generates Δ 1 -2-substituted pyrrolines (2) in good yield. Keto lactams (1) can be further alkylated and hydrolyzed to produce Δ 1 -2,3-disubstituted pyrrolines (4) in good isolated yield