Effect of Metal Ions in Organic Synthesis. part XVI. Knoevenagel Condensations of Aldehydes and Tosylhydrazones with 2,4-Pentanedione by Copper (II) Chloride-Catalyzed Reaction

Abstract

Abstract Based on some of our previous findings on the activity of some metal ions in certain organic reactivities,1 we have now studied the Knoevenagel condensations of aliphatic and aromatic aldehydes or their tosylhydrazone derivatives with 2,4-pentanedione. In the presence of catalytic amounts of anhydrous copper (II) chloride, these compounds react in tetrahydrofuran at room temperature, affording the corresponding alkylidene or arylidene compounds in 48–98% yields.