Concepedia

Metal-free, highly efficient organocatalytic amination of benzylic C–H bonds

Qicai Xue, Jin Xie, Huamin Li, Yixiang Cheng, Chengjian Zhu

Chemical Communications · 2013 · 166 citations · 31 references

DOI

Concepts

Abstract

A new synthetic approach toward direct C-N bond formation through sp(3) C-H activation has been developed under metal-free conditions. Both primary and secondary benzylic C-H substrates could react smoothly with various amines to give only mono-amination products with good to excellent yields.

References

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