Neuropsychobiology · 2008 · 16 citations · 0 references
Life SciencesGeneticsImmunologyHuman GeneticsImmunogeneticsMedical GeneticsAffective DisordersDisease Susceptibility LociHla MatchingHla TypingPsychiatric EpidemiologyPsychiatric GeneticsHla Allele Frequency DistributionHla AllelesHla Genotype AssociationsHla ImmunogeneticsHla Polymorphism AnalysisHla Risk AllelesMolecular Hla TypingPopulation Hla Frequency Analysis
114 patients suffering from an endogenomorphic affective illness were typed for HLA antigens at the A and B loci, and the frequencies were compared with those of a control panel numbering 439 individuals. Using new analytical procedures, a large number of tests were conducted, but no convincing evidence for an association of HLA types with affective disorders was obtained. A reanalysis of the same data, where patients are classified according to Danish diagnostic criteria, yields a marginally significant association of the B locus alleles. The sample sizes for this latter analysis were small, the test criteria are undoubtedly inflated, and no compelling case can be made for a useful association.