Intravenous Infusion of Remifentanil Induces Transient Withdrawal Hyperalgesia Depending on Administration Duration in Rats

Abstract

IV remifentanil induces transient withdrawal hyperalgesia soon after its termination. This hyperalgesia is strongly associated with the duration of exposure to remifentanil. Contrary to our hypothesis, ERK1/2 by itself was not the essential factor involved in the induction of the hyperalgesia.