Dissolution in nasal fluid, retention and anti‐inflammatory activity of fluticasone furoate in human nasal tissue <i>ex vivo</i>

Abstract

FF displayed beneficial properties for nasal application. Its low application volume per spray is a prerequisite for effective drug utilization by avoiding immediate loss by nose runoff or drip down the throat. Sustained dissolution and high tissue binding of FF should contribute towards an extended presence of compounds in nasal tissue as a basis for a prolonged pharmacologic activity.