Effect of Chronic Treatment With the Inducible Nitric Oxide Synthase Inhibitor<i>N</i>-Iminoethyl-<scp>l</scp>-Lysine or With<scp>l</scp>-Arginine on Progression of Coronary and Aortic Atherosclerosis in Hypercholesterolemic Rabbits

Abstract

This is the first study showing that chronic treatment with an iNOS inhibitor, L-NIL, limits progression of preexisting atherosclerosis in hypercholesterolemic rabbits. Increased intimal collagen accumulation may participate in iNOS-induced atherosclerosis progression.