Convenient general preparation of oxygenated monofluoro- and gem-difluoro-5a-androstanes using diethylaminosulphur trifluoride - Concepedia

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Convenient general preparation of oxygenated monofluoro- and gem-difluoro-5a-androstanes using diethylaminosulphur trifluoride

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References

1979

Year

T. G. C. Bird, Peter M. Fredericks, Ewart R. H. Jones, G. D. Meakins

Journal of the Chemical Society Chemical Communications

Chemical EngineeringEngineeringBiochemistryNatural Sciences5α-Androstane SeriesFluorous SynthesisOrganic ChemistryConvenient General PreparationChemistryHalogenationVigorous ConditionsBiomolecular EngineeringDiethylaminosulphur Trifluoride

Abstract

Hydroxy-ketones in the 5α-androstane series are converted into fluoro-ketones by diethylaminosulphur trifluoride under mild conditions; acetoxy-ketones give acetoxydifluorides under more vigorous conditions.