ECSM2, An Endothelial Specific Filamin A Binding Protein That Mediates Chemotaxis

Abstract

This study is the first to characterize a novel cell surface protein ECSM2 that regulates endothelial chemotaxis and tube formation, and interacts with filamin A. These studies implicate a role for ECSM2 in angiogenesis via modulation of the actin cytoskeleton.