Synthesis of Fully Substituted 3‐Formyl‐4‐iodofurans <i>via</i> a Gold(I)‐Catalyzed Oxidation/1,2‐Alkynyl Migration/Cyclization/Iodination Cascade

Abstract

Abstract A highly efficient gold(I)‐catalyzed cascade reaction for the synthesis of fully substituted 3‐formyl‐4‐iodofurans has been developed. Mechanistic investigations indicate a reaction pathway that involves a direct iodination reaction of the organogold intermediate via functionalization of the AuC( sp 2 ) bond, instead of a direct iodination of the 3‐formylfurans. magnified image