International Journal of STD & AIDS · 2006 · 16 citations · 0 references
Veterinary MedicineInfectious DiseasesMicrobiologyInfectious Disease EpidemiologyMedical MicrobiologyMolecular EpidemiologyAntibiotic ResistanceBacterial EpidemiologyBacterial InfectionsMolecular Epidemiology Of ResistanceSexually Transmitted Infection EpidemiologySexually Transmitted InfectionsGonorrhea EpidemiologyMolecular Typing Of BacteriaMolecular Typing Of IsolatesMolecular Typing Of PathogensMolecular Typing Of Resistant IsolatesSexually Transmitted Bacterial InfectionsTetracycline Resistance GenesTetracycline Resistance Plasmids
In 2003, episodes of gonorrhoea caused by ciprofloxacin-resistant strains increased to 15.3% from 11% in 2002. This was coincident with a marked increase in strains characterized as serogroup WI, ciprofloxacin-resistant bearing the tetracycline resistance plasmid. Molecular typing of these strains, using Neisseria gonorrhoeae multiantigen sequence typing (NG-MAST) revealed 71% (34/48) were of the same sequence type, ST338, accounting for 4.1% (34/824) of all strains in 2003. Epidemiological data demonstrated that transmission of ST338 was associated with men who have sex with men (MSM; 23/27), acquisition within the UK (22/26) and having two or more partners in the previous three-month period (18/27). The combined use of highly discriminatory typing and epidemiological surveillance helps to identify successful transmission networks.