Concepedia

Synthesis of Modified Phenylalanine Peptides by Cross Enyne Metathesis and a Diels–Alder Reaction as Key Steps

Sambasivarao Kotha, Deepti Goyal, Niranjan Thota, Venu Srinivas

European Journal of Organic Chemistry · 2012 · 22 citations · 54 references

DOI

Concepts

Abstract

Abstract Modified phenylalanine‐based di‐ and tripeptides have been efficiently assembled by cross enyne metathesis and a Diels–Alder reaction as key steps under mild conditions. In all cases, peptide integrity was preserved, no racemisation was observed, and good yields of modified peptides were obtained.

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