Evaluation of cytochrome P4502C9 metabolic activity with tolbutamide in <i>CYP2C9*1</i> heterozygotes

Abstract

CYP2C9 activity was significantly reduced in (*)1 heterozygotes compared with (*)1 homozygotes, and metabolism was more severely impaired in (*)1/(*)3 individuals compared with those expressing (*)1/(*)2.