Topiramate in Opiate Withdrawal-Comparison with Clonidine and with Carbamazepine/Mianserin

Abstract

Compared to clonidine and carbamazepine/mianserin, a detoxification scheme using high initial and then decreasing doses of topiramate appeared to be appropriate for most patients and as associated with less analgesic and myorelaxant comedication, indicating a more promising efficacy at the used doses.