FEBS Letters · 2001 · 385 citations · 32 references
Life SciencesGeneticsInfectious DiseasesComparative GenomicsGenomicsVirologyPathogen GenomicsViral GeneticsViral Genome OrganizationViral GenomicsViral InfectionsVirus Genome OrganizationDirect Person-to-person TransmissionEnzymesGenetic Diversity Of VirusesGenetic Relationship AnalysisHost Range ComparisonNucleotide ContentViral Pathogenicity GenesVirus Evolutionary Relationships
Monkeypox virus (MPV) causes a human disease which resembles smallpox but with a lower person-to-person transmission rate. To determine the genetic relationship between the orthopoxviruses causing these two diseases, we sequenced the 197-kb genome of MPV isolated from a patient during a large human monkeypox outbreak in Zaire in 1996. The nucleotide sequence within the central region of the MPV genome, which encodes essential enzymes and structural proteins, was 96.3% identical with that of variola (smallpox) virus (VAR). In contrast, there were considerable differences between MPV and VAR in the regions encoding virulence and host-range factors near the ends of the genome. Our data indicate that MPV is not the direct ancestor of VAR and is unlikely to naturally acquire all properties of VAR.
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Julie Thompson, Desmond G. Higgins, Toby J. Gibson · Nucleic Acids Research · 1994 · 64.9K citations · Full text
The complete DNA sequence of vaccinia virus
Scott J. Goebel, Gerard P. Johnson, Marion E. Perkus et al. · Virology · 1990 · 856 citations
Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein
Melanie K. Spriggs, Dennis E. Hruby, C R Maliszewski et al. · Cell · 1992 · 319 citations