IMMUNOHISTOCHEMICAL STUDIES OF S‐100 PROTEIN DURING POSTNATAL ONTOGENESIS OF THE BRAIN OF TWO STRAINS OF RATS

Abstract

Abstract— We have studied the dynamics of the appearance of cells reacting positively with anti‐S‐100 protein antiserum, during postnatal neurocytogenesis in the brain of rats of two strains differing in their susceptibility to sound stimuli. The postnatal time of appearance of cells reacting positively with anti‐S‐100 protein antiserum was somewhat later in rats susceptible to sound‐induced seizures than in sound‐resistant rats. These differences concerned mainly the cerebral cortex of 12‐day‐old rats. By day 21 of postnatal life these differences had disappeared. In subcortical structures of the brain, S‐100 protein was first found on the 4th to the 5th day of life and the rate of appearance of cells containing this protein was similar in the two strains.