A BRADYKININ‐POTENTIATING FACTOR (BPF) PRESENT IN THE VENOM OF <i>BOTHROPS JARARACA</i>

Abstract

Corrado & Rocha e Silva, 1962) it was shown that some metal-binding agents, like dimer- caprol (BAL) and thioglycollic acid, were able to potentiate in vitro and in vivo some of the pharmacological actions of synthetic bradykinin. While determining whether dimercaprol could potentiate in situ the slowly reacting substances released by the venom of Bothrops jararaca when acting on the guinea-pig isolated ileum, it was found that the venom itself had a strong potentiating action upon the concentrations elicited by bradykinin. The present report deals with the chemical nature and biological actions of this bradykinin-potentiating factor (BPF).