Concepedia

Drug Repositioning for Preeclampsia Therapeutics by In Vitro Screening: Phosphodiesterase-5 Inhibitor Vardenafil Restores Endothelial Dysfunction via Induction of Placental Growth Factor

Aiko Kakigano, Takuji Tomimatsu, Kazuya Mimura, Tomoko Kanayama, Satoko Fujita, Kenji Minato, Keiichi Kumasawa, Yukiko Taniguchi, Takeshi Kanagawa, Masayuki Endo,

Reproductive Sciences · 2015 · 17 citations · 25 references

Concepts

MedicineObstetricsPharmacologyClinical PharmacologyMaternal-fetal MedicineWomen's Health PharmacotherapyEclampsiaPregnancy PharmacologyPregnancy-induced HypertensionManagement Of Pre-eclampsiaPharmacotherapy In PregnancyPlacental Dysfunction In PreeclampsiaPlacental Growth Factor SignalingPreeclampsia PathophysiologyPreeclampsia Risk Reduction

References

25

Circulating Angiogenic Factors and the Risk of Preeclampsia

Richard J. Levine, Cong Qian, Lucinda J. England et al. · New England Journal of Medicine · 2004 · 3.6K citations · Full text

Public Health, Maternal Health, Obstetrics +11

Circulating angiogenic factors and the risk of preeclampsia*

Obstetrics and Gynecology · 2004 · 2.6K citations

Medicine, Gynecology, Obstetrics +14

Soluble Endoglin and Other Circulating Antiangiogenic Factors in Preeclampsia

Richard J. Levine, Chun Sing Lam, Cong Qian et al. · New England Journal of Medicine · 2006 · 1.8K citations · Full text

Public Health, Maternal Health, Obstetrics +14

Predicting new molecular targets for known drugs

Michael J. Keiser, Vincent Setola, John J. Irwin et al. · Nature · 2009 · 1.7K citations

Pharmacy, Bioinformatics, Pharmacology +12

β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression

Jeffrey D. Rothstein, Sarjubhai A. Patel, Melissa R. Regan et al. · Nature · 2005 · 1.5K citations

Life Sciences, Neuroscience, Pharmacology +14