Synthesis of 3‐tert‐aminothiophens and their tetrahydro derivatives via enamines

Folkert Albert Buiter, J. Weiland, Hans Wynberg

Recueil des Travaux Chimiques des Pays-Bas · 1964 · 27 citations · 13 references

Concepts

Abstract

Abstract Aromatization of 3‐ketotetrahydrothiophen enamines (II) furnishes 3‐dialkyl‐aminothiophens (III). Reduction of the enamines with formic acid yields the tetrahydro derivatives (V). These compounds represent the first examples of simple 3‐ tert ‐amino‐thiophens and ‐tetrahydrothiophens.

References

13