Pharmacokinetics and pharmacodynamics after oral and intravenous administration of tolcapone, a novel adjunct to Parkinson's disease therapy

Treatment of Parkinson's disease.

R Hardie · PubMed · 1985 · 217 citations

Medicine, Neurology, Pharmacotherapy +11

Pharmacokinetic and pharmacodynamic modeling in vivo.

Nicholas H. G. Holford, Lewis B. Sheiner · PubMed · 1981 · 151 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Tolcapone improves motor function in parkinsonian patients with the"wearing-off" phenomenon

A. H. Rajput, W. R. Wayne Martin, Marie Saint‐Hilaire et al. · Neurology · 1998 · 132 citations

Medicine, Pharmacology, Pharmacotherapy +15

Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone

T. Ker�nen, A. Gordin, MariAnne Karlsson et al. · European Journal of Clinical Pharmacology · 1994 · 126 citations

Medicine, Pharmacokinetics, Pharmacology +8

Pharmacokinetic‐pharmacodynamic interaction between the COMT inhibitor tolcapone and single‐dose levodopa.

Jasper Dingemanse, Karin Jorga, G. Zürcher et al. · British Journal of Clinical Pharmacology · 1995 · 113 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +14