Analysis of Human Genetic Linkage.

TLDR

This book offers a concise introduction to human genetic linkage analysis and gene mapping, and is written so that both genetics professionals and non‑specialist physicians can understand and apply its principles. The book presents mathematical and statistical foundations of linkage analysis, practical guidance on software, problem sets with solutions, and new chapters on complex traits, nonparametric approaches, and two‑locus inheritance.

Abstract

The first and still the only book of its kind, this volume offers a concise introduction to human genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical foundations of linkage analysis for researchers and practitioners, as well as practical comments on available computer programs and websites. Each chapter ends with a set of problems, whose solutions are found at the end of the book. New to this edition is a chapter on complex traits, such as diabetes, some cancers, and psychiatric conditions. Also new is an overview of nonparametric approaches to linkage and association analysis. A chapter on two-locus inheritance introduces the reader to many of the intricate aspects of complex traits. Although the book's primary audience is in the field of genetics, physicians and others without sophisticated training in genetics can understand and apply the principles and techniques discussed.