Aberrant p21 regulation in radioresistant primary glioblastoma multiforme cells bearing wild-type p53

Abstract

These results show that the G, checkpoint and the p53 pathway are dysfunctional in primary GBMs in vitro, despite the presence of an intact p53 gene. The data also suggest that primary GBMs may be divided into two categories on the basis of their p21 response to irradiation.