Protein Kinase Cγ Regulation of Gap Junction Activity through Caveolin-1–Containing Lipid Rafts

Abstract

Activation of PKCgamma by TPA or IGF-1 stimulated the interaction of PKCgamma with Cav-1 and Cx43 in lipid rafts, causing Cx43, Cav-1, and PKCgamma to redistribute within the lipid rafts, and this resulted in a decrease in gap junction plaques.