JAMA · 1993 · 283 citations · 10 references
For patients with newly diagnosed, untreated prostate cancer, a serum PSA concentration of 10.0 micrograms/L or less, and no skeletal symptoms, a staging radionuclide bone scan does not appear to be necessary. This clinical situation applies to 39% of all patients presenting with newly diagnosed prostate cancer. Since more than 130,000 new cases are diagnosed each year, approximately 50,000 patients are affected annually. If the $600 staging bone scan were eliminated for these patients, a significant economic savings to the health care system in this country would be effected.
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Pathologic Differentiation and Prognosis of Prostatic Carcinoma
David C. Utz · JAMA · 1969 · 117 citations
Bone Scanning and Plasma Phosphatases in Carcinoma of the Prostate
E. P. N. OʼDONOGHUE, A. R. Constable, Thomas Sherwood et al. · British Journal of Urology · 1978 · 65 citations