FEBS Letters · 2003 · 27 citations · 43 references
Life SciencesCell BiologyMolecular BiologyCell SignalingProtein-protein InteractionsSignal TransductionCell Signaling NetworksGrowth Factor SignalingHormone ReceptorsIntracellular ReceptorsReceptor RegulationReceptor Tyrosine Kinase SignalingFibroblast Growth Factor Receptor SignalingInsulin ReceptorsInsulin-like Growth Factor Receptor SignalingReceptor Tyrosine Kinase CascadesSrc Homology 2 DomainsTyrosine Kinase Receptor Signaling
The role of Grb7 adapters, Grb7, Grb10, and Grb14, was investigated in Xenopus oocytes expressing fibroblast growth factor receptors (FGFR). FGF-induced maturation of FGFR-expressing oocytes was blocked by previous injection of Grb7 or Grb14, but not Grb10. This effect correlated with Grb7/14 binding to the receptor, and inhibition of the Ras-dependent pathway. Interestingly, the phosphorylated insulin receptor interacting region (PIR) and Src 2 homology domains (SH2) of Grb7 and Grb14 were differently implicated in the inhibition of FGFR signalling. This study provided further evidence for specificity of the biological action of the Grb7 adapters on receptor tyrosine kinase signalling.
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S.H. Ong, Yaron R. Hadari, Noriko Gotoh et al. · Proceedings of the National Academy of Sciences · 2001 · 313 citations · Full text