The Effect of Extracellular Calcium on Thermal Excitability of the Sensory Units in the Tooth of the Cat

Abstract

Abstract Intradental sensory nerve impulse activity was measured from dentinal cavities in canine teeth of anesthetized cats. No spontaneous activity was usually recorded in cavities filled with isotonic saline. Heat stimulation of 15–20 o C failed to give any impulse activity, while other stimuli, such as air blasts produced bursts of impulses. Lowering extracellular calcium ion concentration. by local application of sodium citrate, sodium oxalate or EDTA, induced impulse activity. Under these conditions, heat produced a rapid increase in discharge activity. which lasted as long as the stimulus was applied. Increased extracellular calcium concentration abolished this response to heat. The present findings show that a change in the extracellular calcium ion concentration modulates the excitability of intradental sensory units, and may thus also modulate the resulting experience of pain.