Increased density of <i>Demodex folliculorum</i> and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea

Abstract

Although Demodex mites do not seem to be the cause of rosacea, they may represent an important cofactor, especially in papulopustular rosacea. Immunohistochemical findings suggest that a delayed hypersensitivity reaction, possibly triggered by antigens of follicular origin, probably related to D. folliculorum, may occur, stimulating progression of the affection to the papulopustular stage.