Diastereo‐ and Enantioselective Gold(I)‐Catalyzed Intermolecular Tandem Cyclization/[3+3]Cycloadditions of 2‐(1‐Alkynyl)‐2‐alken‐1‐ones with Nitrones

Abstract

The mysterious cyclizations of gold: An asymmetric gold(I)-catalyzed formal [3+3] cycloaddition of 2-(1-alkynyl)-2-alken-1-ones with nitrones has been developed. Compound 1 was found to be an effective and reliable chiral catalyst, as well as the commonly used 2, for this gold-catalyzed reaction. Tf=trifluoromethanesulfonyl.