Constant denaturant gel electrophoresis, a modification of denaturing gradient gel electrophoresis, in mutation detection

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

Randall K. Saiki, David H. Gelfand, Susanne Stoffel et al. · Science · 1988 · 17.2K citations

Life Sciences, Biotechnology, Molecular Biology +12

Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes.

Val C. Sheffield, David R. Cox, Leonard S. Lerman et al. · Proceedings of the National Academy of Sciences · 1989 · 1.3K citations · Full text

Life Sciences, Genetics, Molecular Biology +14

DNA fragments differing by single base-pair substitutions are separated in denaturing gradient gels: correspondence with melting theory.

S G Fischer, Leonard S. Lerman · Proceedings of the National Academy of Sciences · 1983 · 891 citations · Full text

Life Sciences, Molecular Biology, Dna Replication +10

Detection of single base substitutions in total genomic DNA

R Myers, Nadya Lumelsky, Leonard S. Lerman et al. · Nature · 1985 · 376 citations

Life Sciences, Genetics, Molecular Genetics +11

Sequence-Determined DNA Separations

Leonard S. Lerman, S G Fischer, Ian P. Hurley et al. · Annual Review of Biophysics and Bioengineering · 1984 · 208 citations

Life Sciences, Genetics, Molecular Genetics +17