Physics in Medicine and Biology · 2005 · 350 citations · 22 references
MedicineRadiation OncologyRadiologyRadiation DosimetryRadiation TransportTreatment PlanningElectron DosimetryExternal Beam RadiotherapyMagnetic Resonance ImagingMonte Carlo DosimetryPhantom DosimetryRadiation TherapyExternal Beam Dose DistributionExternal Beam Radiotherapy DosimetryLateral Dose ProfilesMagnetic Field DependenceMonte Carlo Dose SimulationMonte Carlo Phantom DosimetryPhantom-based Dose MeasurementTissue Boundaries
The electron return effect causes dose increases at tissue–air interfaces and dose decreases behind air cavities. The study aims to quantify how a lateral magnetic field influences dose distribution in an MRI‑linear accelerator integration and to evaluate its impact in realistic IMRT geometries and potential therapeutic use near air cavities. The authors used GEANT4 Monte Carlo simulations of a water–air–water phantom and film measurements in a perspex–air–perspex phantom under a lateral magnetic field to model the electron return effect. Simulations and experiments confirm the electron return effect, but IMRT with multiple beam directions mitigates exit‑dose concerns, and opposite beam configurations yield relatively flat dose profiles despite localized increases and decreases.
In the framework of the development of the integration of a MRI-scanner with a linear accelerator, the influence of a lateral, magnetic field on the dose distribution has to be determined. Dose increase is expected at tissue-air boundaries, due to the electron return effect (ERE): electrons entering air will describe a circular path and return into the phantom causing extra dose deposition. Using IMRT with many beam directions, this exit dose will not constitute a problem. Dose levels behind air cavities will decrease because of the absence of electrons crossing the cavity. The ERE has been demonstrated both by simulation and experiment. Monte Carlo simulations are performed with GEANT4, irradiating a water–air–water phantom in a lateral magnetic field. Also an air tube in water has been simulated, resulting in slightly twisted regions of dose increase and decrease. Experimental demonstration is achieved by film measurement in a perspex–air–perspex phantom in an electromagnet. Although the ERE causes dose increase before air cavities, relatively flat dose profiles can be obtained for the investigated cases using opposite beam configurations. More research will be necessary whether this holds for more realistic geometries with the use of IMRT and whether the ERE can be turned to our advantage when treating small tumour sites at air cavities.
22
Prescribing, recording, and reporting photon beam therapy
Icru · Medical Entomology and Zoology · 1993 · 2K citations
Tomotherapy: A new concept for the delivery of dynamic conformal radiotherapy
T Mackie, Timothy Holmes, Stuart Swerdloff et al. · Medical Physics · 1993 · 1.1K citations · Full text