Age and Ageing · 1991 · 28 citations · 0 references
MedicineBiochemistryPharmacologyAgingDrug MetabolismEnzymologyAge-related Physiological ChangesHepatic Drug MetabolismHepatic MetabolismLiver DiseaseAge-dependent MetabolismAge-related Enzyme Activity ChangesEnzyme ActivityEsterase ActivityHepatic AgingHepatic Enzyme AlterationsHepatic Function ChangesLiver Metabolism In Aging
The activity of the phase 1 enzyme aspirin esterase was studied in liver tissue from 16 patients, aged 45-88 years. No correlation between age and enzyme activity was found in post-mitochondrial, cytosolic and microsomal fractions. These results provide further evidence that age is not a major determinant of the activity of hepatic drug-metabolizing enzymes in man.