Protective Action of Certain Amino Acids on Toxicity of Mercurial Diuretics in Rats

Abstract

Certain amino acids reduce considerably the nephrotoxic action of meralluride sodium in the rat. Among the amino acids examined 1(+) arginine monohydrochlorid and glycine were found to be most effective. The beneficial influence seen in microscopic sections as well as in the reduced proteinuria following a toxic dose of the mercurial diuretic is attributed to the competitive suppression of tubular reabsorption of the injurious mercury.