Novel pyridopyrimidine derivatives as inhibitors of stable toxin a (STa) induced cGMP synthesis

Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine.

Michael Field, Liselotte Graf, W Laird et al. · Proceedings of the National Academy of Sciences · 1978 · 565 citations · Full text

Life Sciences, Biochemistry, Microbiology +17

Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli

James M. Hughes, Ferid Murad, Bing Chang et al. · Nature · 1978 · 366 citations

Life Sciences, Biochemistry, Microbiology +15

Dihydropyrido[2,3-d]pyrimidines as a new class of antileishmanial agents

Anu Agarwal, Ramesh Ramesh, Ashutosh Ashutosh et al. · Bioorganic & Medicinal Chemistry · 2005 · 152 citations

Medicine, Medicinal Chemistry, Pharmacology +8

Structure and function of the heat-stable enterotoxin receptor/guanylyl cyclase C

Arie B. Vaandrager · Molecular and Cellular Biochemistry · 2002 · 118 citations · Full text

Life Sciences, Biochemistry, Pharmacology +12

Three-component synthesis and anticancer evaluation of polycyclic indenopyridines lead to the discovery of a novel indenoheterocycle with potent apoptosis inducing properties

Madhuri Manpadi, Pavel Y. Uglinskii, Shiva K. Rastogi et al. · Organic & Biomolecular Chemistry · 2007 · 105 citations

Natural Sciences, Chemistry, Medicinal Chemistry +15