Sensitive NMR Sensors Detect Antibodies to Influenza

Isaac Koh, Ralph Weissleder, Lee Josephson

Angewandte Chemie International Edition · 2008 · 85 citations · 19 references

DOIFull text

Open access

Concepts

Abstract

Catching the flu: Magnetic particle aggregation has been used to provide a highly sensitive, NMR-based sensor for detecting antibodies to an influenza virus. To achieve high sensitivity, a homogeneous magnetic field (H) was employed to enhance antibody-based cross-linking between particles suspended in solution (see scheme; ΔT2: change in the transverse relaxation time).

References

19