Guanidine-catalyzed Asymmetric Addition Reactions: Michael Reaction of Cyclopentenone with Dibenzyl Malonates and Epoxidation of Chalcone

Abstract

Several kinds of modified guanidines designed by us were applied to two types of asymmetric synthesis as superbases: Michael reactions of cyclopentenone with dibenzyl malonates and epoxidation of chalcone.Good to moderate asymmetric inductions were observed in these guanidine-catalyzed reactions.