A novel hydride rearrangement of the acetal group of tetraacetal tetraoxa-cages mediated by Lewis acids

Abstract

Treatment of tetraoxa-cages 1a–f with Lewis acids such as TiCl 4 , AlCl 3 , BF 3 ·OEt 2 and MeSO 3 H in dichloromethane at 25 °C gives the rearrangement products 2a–f in 90% yields regioselectively and stereoselectively; a novel hydride rearrangement of the acetal group of tetraacetal tetraoxa-cages mediated by Lewis acids.