Angewandte Chemie International Edition · 1999 · 15 citations · 0 references
Natural SciencesChemical EngineeringChemistryCatalysisReaction EngineeringSolid-state ChemistryCatalytic MaterialsOxidation-reduction ReactionsRedox CatalysisRedox ChemistrySolid-state ReactionsSupported CatalystsAtom Transfer CatalysisCoupled Oxidation-reduction ProcessesNitro CompoundsNitro ReductionPhase-transfer CatalystsRedox SynthesisReduction Of Nitroaromatic CompoundsSolid-phase Catalysis
A wide range of aromatic nitro compounds can be reduced to anilines through the use of a Cr(II)/Mn(0) redox couple in the presence of trimethylsilyl chloride [TMSCl, Eq. (1)]. Only 0.25 equivalents of chromium are required to reduce solid-supported nitroarenes (R=solid support); this represents a rare case of transfer catalysis between two solid phases. The reaction is also amenable to solution-phase synthesis (R=OH).