A Prospective, Randomized, Parallel Group Study Analyzing the Effect of BTX-A (Botox) and Nonanimal Sourced Hyaluronic Acid (NASHA, Restylane) in Combination Compared with NASHA (Restylane) Alone in Severe Glabellar Rhytides in Adult Female Subjects: Treatment of Severe Glabellar Rhytides with a Hyaluronic Acid Derivative Compared with the Derivative and BTX-A

Abstract

By comparison with the NASHA-alone group, the BTX-A plus NASHA group showed a better response both at rest and on maximum frown, and this response was maintained for longer. The median time for return to preinjection furrow status occurred at 18 weeks in the NASHA-alone group compared with 32 weeks for the BTX-A plus NASHA group.