Degradable magnesium‐based implant materials with anti‐inflammatory activity

Abstract

Abstract The objective of this study was to prepare a new biodegradable Mg‐based biomaterial, which provides good mechanical integrity in combination with anti‐inflammatory function during the degradation process. The silver element was used, because it improved the mechanical properties as an effective grain refiner and it is also treated as a potential anti‐inflammatory core. The new degradable Mg‐Zn‐Ag biomaterial was prepared by zone solidification technology and extrusion. The mechanical properties were mostly enhanced by fine grain strengthening. In addition, the alloys exhibited good cytocompatibility. The anti‐inflammatory function of degradation products was identified by both interleukin‐1α and nitric oxide modes. The anti‐inflammatory impact was significantly associated with the concentration of silver ion. It was demonstrated that Mg‐Zn‐Ag system was a potential metallic stent with anti‐inflammatory function, which can reduce the long‐term dependence of anti‐inflammatory drug after coronary stent implantation. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.