Green Chemistry · 2002 · 39 citations · 15 references
Natural SciencesChemical EngineeringChemistryCatalysisGreen ChemistryOrganic ChemistryCatalytic MaterialsCatalytic Reaction EngineeringHeterocycle SynthesisMacrocycle SynthesisMicrowave-assisted SynthesisOrganic SynthesisChemical SubstituentsLewis Acid CatalysisLewis AcidityMicrowave-assisted C-h FunctionalizationMicrowave-assisted CatalysisMicrowave-assisted Condensation ReactionsMicrowave-assisted Organic SynthesisPosition
The Bernthsen reaction is studied using microwaves as the heat source. This leads to acridines with aromatic and aliphatic substituents in position 9, shortening reaction times and increasing yields, with a reduction in Lewis acid catalyst (ZnCl2), allowing a more environmentally friendly reaction.
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Susanne Bonse, Christiane Santelli‐Rouvier, Jacques Barbe et al. · Journal of Medicinal Chemistry · 1999 · 101 citations · Full text