NMR Studies of Cyclodextrin Inclusion Complex

Abstract

Abstract Cyclodextrins1,2 (CDs) are cyclic oligosaccharides composed of six or more (1→4) linked α-D-glucopyranosyl residues (see FIG. 1). The common CDs are called α-, β-, and γ-CD and are constructed of six, seven, and eight α-D-glucopyranosyl units, respectively. The CD molecule is a toroidal, hollow, truncated cone with primary and secondary hydroxyl groups crowning the narrower and the wider rims, respectively. Methine protons and glucosidic oxygens are oriented in its interior and the space inside the hollow, called the cavity, is relatively hydrophobic. The internal diameter of the cavity is about 5∼9 Å for the common CDs.