Transactions of the Royal Society of Tropical Medicine and Hygiene · 1982 · 18 citations · 15 references
Veterinary MedicineInfectious DiseasesPharmacologyDiagnostic MicrobiologyDrug DiscoveryTransfusion MedicineBlood Parasite DiagnosisBlood ParasitesBlood Transfusion SafetyChagas DiseaseInfectious Disease Molecular TestingRapid Diagnostic TestsBlood Transfusion TherapyBlood Transfusion TransmissionChagas Disease ScreeningFalse-positive ResultsTransfusion-transmitted Infection TestingTrypanosoma Cruzi InfectionTrypanosome DetectionTrypanosomiasis Transmission
This paper describes how Microslide tubes can be used as the basis for a quick, simple, inexpensive screen to test for compounds which might prevent the transmission of Chagas's disease as a result of blood transfusion. The test uses Trypanosoma cruzi-infected mouse blood and requires only very small amounts of compound. The screen identifies compounds known to be active against blood trypomastigotes in vitro at 4 degrees C, and is apparently free of false negative and positive results.
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