Open Journal of Gastroenterology · 2014 · 17 citations · 22 references
MedicinePharmacologyPharmacotherapyClinical PharmacologyGastrointestinal PharmacotherapyPain ManagementFunctional Gastrointestinal DisordersGastroesophageal Reflux DiseaseGastroesophageal Reflux Disease CareGastrointestinal PharmacologyHeartburn ManagementFunctional Pain SyndromesGastroesophageal Reflux Disease PharmacotherapyGerd Symptom AssessmentMelatonin PharmacologyMelatonin SupplementationMelatonin TreatmentPharmacologic Therapy For GerdPlacebo-controlled Efficacy Assessment
Background: Melatonin is a safe and effective treatment for patients with functional pain and gastrointestinal disorders. Objective: To evaluate the efficacy and safety of melatonin for 3 months in patients with functional heartburn. Methods: In the randomized, placebo-controlled pilot study, patients with functional heartburn were treated with omeprazole 20 mg before breakfast and randomized to receive either melatonin 6 mg (n = 20), nortripty line 25 mg (n = 20), or placebo (n = 20) at bedtime for 3 months. Gastroesophageal Reflux Disease-Health-Related Quality of Life (GERD-HRQOL) scores were assessed at baseline and at the end of the study. Results: Melatonin improved GERD-HRQOL scores compared with nortriptyline (P = 0.0015) and placebo (P
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Melatonin: A peroxyl radical scavenger more effective than vitamin E
Carlo Pieri, Maurizio Marra, Fausto Moroni et al. · Life Sciences · 1994 · 739 citations
Melatonin Treatment for Age-Related Insomnia
Irina V. Zhdanova, Richard J. Wurtman, Meredith M. Regan et al. · The Journal of Clinical Endocrinology & Metabolism · 2001 · 278 citations