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Correction of a mineralization defect by overexpression of a wild-type cDNA for COL1A1 in marrow stromal cells (MSCs) from a patient with osteogenesis imperfecta: a strategy for rescuing mutations that produce dominant-negative protein defects

Bone RepairOsteogenesisOsteoporosisOrthopaedic SurgeryRegenerative MedicineBone DiseaseBone Marrow FailureBone Morphogenic ProteinHematologyStem CellsHealth SciencesDominant-negative Protein DefectsCell BiologyOsteogenesis ImperfectaOsteocalcinDevelopmental BiologyStem Cell ResearchMineralization DefectMedicine