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Gerald M. Reaven · Diabetes · 1988 · 3.8K citations

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The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones

Timothy M. Willson, Jeffery E. Cobb, David J. Cowan et al. · Journal of Medicinal Chemistry · 1996 · 639 citations · Full text

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Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice.

Philip J. Bailey, Chhabi Biswas, Catherine A. Cullinan et al. · Endocrinology · 1996 · 381 citations

Medicine, Endocrinology, Pharmacology +14

Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice

Endocrinology · 1996 · 127 citations

Medicine, Pharmacology, Cell Signaling +15

Characterization of CS-045, a new oral antidiabetic agent, II. Effects on glycemic control and pancreatic islet structure at a late stage of the diabetic syndrome in - mice

Toshihiko Fujiwara, Mikiyo Wada, Kuniaki Fukuda et al. · Metabolism · 1991 · 116 citations

Medicine, Endocrinology, Pharmacology +17