Synthesis of conformationally constrained analogues of (R)-2-amino-7-phosphonoheptanoic acid

The Utility of Phosphonate Carbanions in Olefin Synthesis

William S. Wadsworth, William D. Emmons · Journal of the American Chemical Society · 1961 · 1.4K citations

Natural Sciences, Chemistry, Analytical Chemistry +4

THE EFFECTS OF A SERIES OF ω‐PHOSPHONIC α‐CARBOXYLIC AMINO ACIDS ON ELECTRICALLY EVOKED AND EXCITANT AMINO ACID‐INDUCED RESPONSES IN ISOLATED SPINAL CORD PREPARATIONS

Richard H. Evans, A. A. Francis, Alan Wayne Jones et al. · British Journal of Pharmacology · 1982 · 466 citations · Full text

Life Sciences, Neuroscience, Pharmacology +16

2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation

J. Davies, A. A. Francis, Alan Wayne Jones et al. · Neuroscience Letters · 1981 · 464 citations

Life Sciences, Neuroscience, Pharmacology +14

Synthesis and NMD A Antagonistic Properties of the Enantiomers of 4‐(3‐phosphonopropyl)piperazine‐2‐carboxylic acid (CPP) and of the unsaturated analogue (<i>E</i>)‐4‐(3‐phosphonoprop‐2‐enyl)piperazine‐2‐carboxylic acid (CPP‐ene)

Bernard Aebischer, P.A. Frey, H. P. HAERTER et al. · Helvetica Chimica Acta · 1989 · 109 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

4-(Phosphonoalkyl)- and 4-(phosphonoalkenyl)-2-piperidinecarboxylic acids: synthesis, activity at N-methyl-D-aspartic acid receptors and anticonvulsant activity

Alan Hutchison, Michael Williams, Christof Angst et al. · Journal of Medicinal Chemistry · 1989 · 79 citations

Medicine, Neuroscience, Pharmacology +17