Cervicovaginal HIV-1 and herpes simplex virus type 2 shedding during genital ulcer disease episodes

Abstract

Genital HSV-2 infection is associated with increased cervicovaginal and plasma HIV-1 RNA among co-infected women with genital ulcers, independently of the level of immunodeficiency, highlighting the close interaction between these two viruses and the role of HSV-2 as a co-factor for the sexual transmission of HIV-1.