Journal of Antimicrobial Chemotherapy · 1993 · 27 citations · 5 references
Life SciencesInfectious DiseasesMicrobiologyAntimicrobial ResistanceBacteriologyMedical MicrobiologyAntibacterial PharmacologyAntibiotic ResistanceAntibiotic Resistance MechanismsAntimicrobial PharmacodynamicsBacterial InfectionsMultidrug ResistanceAntibiotic PharmacodynamicsAntibiotic-resistant Pathogen ControlAntimicrobial ChemotherapyCephalosporin TherapyFosfomycin ResistanceFosfomycin TherapyPenicillin ResistanceSpectrum Of Beta-lactam Antibiotics
The killing kinetics of cefotaxime and fosfomycin, alone and in combination, against seven clinical isolates of penicillin-resistant pneumococci were studied. The antibiotics were tested at 1 x, 2 x and 4 x the MIC for each individual isolate. The results showed a synergic interaction of the two antibiotics for three of the seven strains. This strategy may be useful clinically.
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Emergence of Multiply Resistant Pneumococci
Michael R. Jacobs, H. J. Koornhof, Roy M. Robins‐Browne et al. · New England Journal of Medicine · 1978 · 634 citations